Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106135 | 0.83 | KMT2A (0.55) | MAOBMAOAKMT2AMEN1KDM4E | |
| SCHEMBL30084798 | 0.75 | CCR1 (0.47) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL27828993 | 0.74 | IKBKB (0.50) | MAOBMAOAKMT2AMEN1KDM4E | |
| SCHEMBL6277586 | 0.73 | KMT2A (0.55) | MAOAKMT2AMEN1KDM4EMETAP2 | |
| SCHEMBL6565245 | 0.72 | DAO (0.41) | MAOBMAOAKMT2AMEN1KDM4E | |
| SCHEMBL3246323 | 0.71 | METAP2 (0.56) | KMT2AMEN1KDM4EMETAP2PIM1 | |
| SCHEMBL11871238 | 0.71 | KMT2A (0.45) | KMT2AMEN1KDM4EMETAP2PIM1 | |
| SCHEMBL1051386 | 0.70 | KDM4E (0.71) | KMT2AMEN1KDM4EMETAP2PIM1 | |
| SCHEMBL28255583 | 0.70 | KDM4E (0.51) | MAOAKMT2AMEN1KDM4EMETAP2 | |
| SCHEMBL28756690 | 0.70 | KDM4E (0.51) | KMT2AMEN1KDM4EMETAP2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327934-A1 | Device and method for carrying out extemporaneous quantitative diagnostic tests on the whole blood | Beli, Raffaele (IT) | 1989-08-16 | — | — | EP | claimed |
| US-11898180-B2 | Compositions and methods for amino acid depletion therapy | AVALON POLYTOM (HK) LIMITED (HK) | 2024-02-13 | — | — | US | disclosed |
| US-20240009283-A1 | Compositions Of Engineered Human Arginases And Methods For Treating Cancer | AERASE, INC. (US) | 2024-01-11 | — | — | US | disclosed |
| EP-3778885-B1 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | AERASE INC (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-3957727-A1 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | AERase, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3957728-A1 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | AERase, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210189370-A1 | COMPOSITIONS AND METHODS FOR AMINO ACID DEPLETION THERAPY | AVALON POLYTOM (HK) LIMITED (HK) | 2021-06-24 | — | — | US | disclosed |
| US-20210128703-A1 | Compositions Of Engineered Human Arginases And Methods For Treating Cancer | AERASE, INC. (US) | 2021-05-06 | — | — | US | disclosed |
| EP-3778885-A1 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | AERase, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3064579-B1 | PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES OF ENGINEERED HUMAN ARGINASES | AERASE INC (US) | 2020-09-30 | — | — | EP | disclosed |
| US-8440184-B2 | Compositions of engineered human arginases and methods for treating cancer | GMA TECHNOLOGIES LLC (US) | 2013-05-14 | — | — | US | disclosed |
| US-20120177628-A1 | ARGINASE FORMULATIONS AND METHODS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-07-12 | — | — | US | disclosed |
| EP-2449102-A2 | ARGINASE FORMULATIONS AND METHODS | The Board of Regents of The University of Texas System (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2411040-A1 | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents | The Hong Kong Polytechnic University (CN) | 2012-02-01 | — | — | EP | disclosed |
| EP-2350273-A2 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | The Board of Regents of The University of Texas System (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2011008495-A2 | ARGINASE FORMULATIONS AND METHODS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010124547-A1 | SITE-DIRECTED PEGYLATION OF ARGINASES AND THE USE THEREOF AS ANTI-CANCER AND ANTI-VIRAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2010-11-04 | — | — | WO | disclosed |
| US-20100247508-A1 | SITE-DIRECTED PEGYLATION OF ARGINASES AND THE USE THEREOF AS ANTI-CANCER AND ANTI-VIRAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2010-09-30 | — | — | US | disclosed |
| WO-2010051533-A2 | COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-05-06 | — | — | WO | disclosed |
| US-20100111925-A1 | Compositions of Engineered Human Arginases and Methods for Treating Cancer | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-05-06 | — | — | US | disclosed |