Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567173 | 0.78 | LMNA (0.49) | KDM4EALDH1A1GLANQO2MEN1 | |
| SCHEMBL4191610 | 0.75 | MAOB (0.40) | KDM4EALDH1A1MAOAMAOBXPO1 | |
| SCHEMBL6565243 | 0.75 | MCHR1 (0.48) | KDM4EALDH1A1MAOAMAOBMEN1 | |
| SCHEMBL6565257 | 0.74 | TTR (0.41) | KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL2975427 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1GLATHRBMEN1 | |
| SCHEMBL472242 | 0.72 | MAOB (0.50) | KDM4EALDH1A1THRBMAOAMAOB | |
| SCHEMBL6565264 | 0.72 | MCHR1 (0.51) | MEN1TSHRKMT2A | |
| SCHEMBL6564114 | 0.71 | POLB (0.45) | KDM4EALDH1A1GLAMEN1TSHR | |
| SCHEMBL6567192 | 0.70 | MCHR1 (0.53) | MEN1KMT2A | |
| SCHEMBL29554697 | 0.70 | DHODH (0.50) | KDM4ETHRBMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |