Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717730 | 0.89 | MAPT (0.48) | BCAT2MAPTLMNAHTTKMT2A | |
| SCHEMBL4721414 | 0.87 | MAPT (0.46) | BCAT2NPC1MAPTLMNAHTT | |
| SCHEMBL290505 | 0.85 | KDM4E (0.48) | NPC1MAPTLMNAHTTKMT2A | |
| SCHEMBL4542766 | 0.81 | NOTUM (0.41) | BCAT2MAPTLMNAHTTNOTUM | |
| SCHEMBL5462039 | 0.80 | MAPT (0.49) | MAPTLMNAHTTKMT2ASRC | |
| SCHEMBL4722651 | 0.77 | PDE4A (0.42) | BCAT2MAPTLMNAHTTNOTUM | |
| SCHEMBL290869 | 0.77 | HPGD (0.48) | BCAT2MAPTLMNAHTTKMT2A | |
| SCHEMBL4718179 | 0.77 | NPC1 (0.41) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL4720274 | 0.76 | BCAT2 (0.43) | BCAT2NPC1MAPTLMNAHTT | |
| SCHEMBL4720241 | 0.76 | MAPT (0.46) | BCAT2MAPTLMNAHTTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | claimed |
| CN-115192711-A | Use of PDE7 inhibitors for the treatment of movement disorders | 奥默罗斯公司 | 2022-10-18 | — | — | CN | disclosed |