Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721657 | 0.90 | KDR (0.41) | GPR119KDRBRAFERBB2 | |
| SCHEMBL390908 | 0.88 | GPR119 (0.51) | GPR119THRB | |
| SCHEMBL4721923 | 0.87 | GPR119 (0.39) | GPR119KDRBRAFFLT3CDK2 | |
| SCHEMBL4720846 | 0.87 | GPR119 (0.41) | GPR119KDRFLT3CDK2CDK6 | |
| SCHEMBL4719350 | 0.86 | GPR119 (0.40) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4722419 | 0.86 | GPR119 (0.41) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4719081 | 0.84 | GPR119 (0.48) | GPR119KDRBRAFFLT3CDK2 | |
| SCHEMBL4719882 | 0.84 | ERBB2 (0.39) | GPR119KDRFLT3CDK2CDK6 | |
| SCHEMBL4721904 | 0.84 | TRPV1 (0.44) | GPR119THRBFLT3CDK2CDK6 | |
| SCHEMBL4720714 | 0.83 | GPR119 (0.40) | GPR119FLT3CDK2CDK6ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |