Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720714 | 0.90 | GPR119 (0.40) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4723643 | 0.90 | FLT3 (0.38) | GPR119FLT3CDK2CDK6KDR | |
| SCHEMBL4721923 | 0.88 | GPR119 (0.39) | GPR119FLT3CDK2CDK6KDR | |
| SCHEMBL388816 | 0.88 | GPR119 (0.49) | GPR119JAK2JAK1 | |
| SCHEMBL4719349 | 0.87 | GPR119 (0.46) | GPR119FLT3CDK2CDK6JAK2 | |
| SCHEMBL4723304 | 0.87 | GPR119 (0.42) | GPR119FLT3CDK2CDK6KDR | |
| SCHEMBL4719852 | 0.87 | GPR119 (0.41) | GPR119FLT3CDK2CDK6JAK2 | |
| SCHEMBL4721657 | 0.85 | KDR (0.41) | GPR119MAPK14KDR | |
| SCHEMBL4718549 | 0.84 | GPR119 (0.46) | GPR119FLT3CDK2CDK6KDR | |
| SCHEMBL4720662 | 0.83 | PIK3CA (0.42) | GPR119FLT3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |