Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.42 |
| ▸ | CCR3 | P51677 | 3/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3196716 | 0.93 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3198122 | 0.89 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3205843 | 0.89 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL4237706 | 0.89 | RORC (0.48) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL10315551 | 0.88 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3196731 | 0.88 | RORC (0.50) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3214447 | 0.88 | CCR3 (0.51) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| Omecamtiv Mecarbil SCHEMBL400544 | 0.87 | RORC (0.47) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL5070131 | 0.87 | RORC (0.47) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| Omecamtiv Mecarbil SCHEMBL29400097 | 0.87 | RORC (0.47) | NPC1RAB9ASMN1; SMN2RORCDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | claimed |