Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
| ▸ | CCR3 | P51677 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3196716 | 0.95 | NPC1 (0.53) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3196731 | 0.93 | RORC (0.50) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| Omecamtiv Mecarbil SCHEMBL400544 | 0.92 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| Omecamtiv Mecarbil SCHEMBL29400097 | 0.92 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5070131 | 0.92 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4242343 | 0.92 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3189243 | 0.92 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3214918 | 0.92 | RORC (0.49) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3198122 | 0.91 | NPC1 (0.49) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL402588 | 0.91 | ALDH1A1 (0.52) | RORCDHODHNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247544-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2009-10-01 | — | — | US | claimed |
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| US-20070197505-A1 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. | 2007-08-23 | — | — | US | claimed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | claimed |
| US-20230373955-A1 | SYNTHESIS OF OMECAMTIV MECARBIL | AMGEN INC. | 2023-11-23 | — | — | US | disclosed |
| US-11753394-B2 | Synthesis of omecamtiv mecarbil | AMGEN INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11702380-B2 | Synthesis of omecamtiv mecarbil | AMGEN INC. (US) | 2023-07-18 | — | — | US | disclosed |
| EP-3594199-B1 | CRYSTALLINE 2-FLUORO-3-NITROTOLUENE AND PROCESS FOR THE PREPARATION THEREOF | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2020-07-01 | — | — | EP | disclosed |
| WO-2020011626-A1 | CRYSTALLINE 2-FLUORO-3-NITROTOLUENE AND PROCESS FOR THE PREPARATION THEREOF | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-01-16 | — | — | WO | disclosed |
| US-20090247544-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2009-10-01 | — | — | US | disclosed |
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| US-20070197505-A1 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702380-B2 | Synthesis of omecamtiv mecarbil | SI, MTHFD2, DPYD | RORC 2185/4885DHODH 18/4885NPC1 4461/4885 |
| US-20070197505-A1 | Certain chemical entities, compositions and methods | TNNC1, TNNI3, TNNT2 | RORC 2707/4885DHODH 3410/4885NPC1 4826/4885 |
| US-20230373955-A1 | SYNTHESIS OF OMECAMTIV MECARBIL | DPYD, SI, MTHFD2 | RORC 2556/4885DHODH 10/4885NPC1 4214/4885 |
| US-11753394-B2 | Synthesis of omecamtiv mecarbil | SI, DPYD, MTHFD2 | RORC 2157/4885DHODH 7/4885NPC1 4317/4885 |
| US-20090247544-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | RORC 2707/4885DHODH 3410/4885NPC1 4826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.