Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723090 | 0.85 | PIN1 (0.49) | PIN1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL28926222 | 0.80 | PIN1 (0.53) | PIN1KMT2AMEN1GAALMNA | |
| SCHEMBL168495 | 0.80 | PIN1 (0.50) | PIN1KMT2AMEN1HTR1AADRA1D | |
| SCHEMBL31234027 | 0.80 | PIN1 (0.53) | PIN1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1937604 | 0.80 | PIN1 (0.53) | PIN1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL23887837 | 0.79 | ADORA1 (0.44) | KMT2ANPC1RAB9AMEN1HTR1A | |
| SCHEMBL16879230 | 0.77 | KMT2A (0.60) | KMT2ANPC1RAB9AMEN1GAA | |
| SCHEMBL23925083 | 0.77 | PIN1 (0.45) | PIN1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL29989486 | 0.77 | PIN1 (0.45) | PIN1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL31554570 | 0.77 | PIN1 (0.49) | PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101330916-A | Substituted imidazoquinolines, imidazonaphthyridines, and imidazopyridines, compositions, and methods thereof | COLEY PHARMACEUTICAL INC (US) | 2008-12-24 | — | — | CN | disclosed |
| EP-1968587-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | Coley Pharmaceutical, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |