Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | PTPRA | P18433 | 1/20 | 0.56 |
| ▸ | PKLR | P30613 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11554842 | 0.90 | PKM (0.61) | PKMPKLRMAPTMEN1KMT2A | |
| SCHEMBL4260125 | 0.88 | PKM (0.55) | PKMPTPRAPKLRCYP2C19MAPT | |
| SCHEMBL14823139 | 0.82 | PKM (0.70) | PKMCYP2C19MAPTMEN1KMT2A | |
| SCHEMBL22777919 | 0.82 | PTPRA (0.67) | PKMPTPRAPKLRCYP2C19MAPT | |
| SCHEMBL7380735 | 0.81 | PTPRA (0.73) | PKMPTPRAPKLRCYP2C19MAPT | |
| SCHEMBL10265469 | 0.81 | PKM (0.69) | PKMPTPRAPKLRCYP2C19MAPT | |
| SCHEMBL5175380 | 0.81 | PKM (0.68) | PKMCYP2C19MAPTMEN1KMT2A | |
| SCHEMBL22777978 | 0.80 | PTPRA (0.58) | PKMPTPRAPKLRCYP2C19MAPT | |
| SCHEMBL10289733 | 0.80 | PKM (0.67) | PKMCYP2C19MAPTMEN1KMT2A | |
| SCHEMBL4261621 | 0.80 | PKM (0.67) | PKMCYP2C19MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2008-02-06 | — | — | EP | disclosed |
| WO-2007063418-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-06-07 | — | — | WO | disclosed |