SCHEMBL4724280

SCHEMBL4724280

COc1ccc(CN2CCC(C(CCC(CCC3CCN(Cc4ccc(Oc5ccccc5)cc4)CC3)C(=O)c3ncco3)C(=O)c3ncco3)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FAAH O00519 13/20 0.57
ACHE P22303 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4659075 0.77 FAAH (0.44) FAAH
SCHEMBL4193240 0.76 FAAH (0.85) FAAH
SCHEMBL4659119 0.74 FAAH (0.56) FAAH
SCHEMBL4658122 0.74 FAAH (0.47) FAAH
SCHEMBL4187021 0.74 FAAH (1.00) FAAH
SCHEMBL3753136 0.73 FAAH (0.58) FAAH
SCHEMBL4659170 0.72 FAAH (0.49) FAAH
SCHEMBL4657857 0.71 FAAH (0.52) FAAH
SCHEMBL3749146 0.71 FAAH (0.68) FAAH
SCHEMBL4659078 0.70 FAAH (0.46) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1954137-A4 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2008-12-17 EP claimed
EP-1954137-A2 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2008-08-13 EP claimed
WO-2007061862-A2 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-05-31 WO claimed