Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.47 |
| ▸ | RAC1 | P63000 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29847698 | 0.85 | TSHR (0.70) | LMNATSHRMAPK1KDM4EMTNR1A | |
| SCHEMBL1496491 | 0.85 | TSHR (0.70) | LMNATSHRMAPK1KDM4EMTNR1A | |
| SCHEMBL29670114 | 0.85 | LMNA (0.63) | LMNAMAPK1KDM4E | |
| SCHEMBL7973999 | 0.85 | LMNA (0.63) | LMNAMAPK1KDM4E | |
| SCHEMBL1496625 | 0.84 | LMNA (0.67) | LMNATSHRMAPK1KDM4EMAPT | |
| SCHEMBL773178 | 0.81 | KMT2A (0.59) | ABCB11TSHRMAPK1CYP1A2CYP2A6 | |
| SCHEMBL20719974 | 0.80 | CA12 (0.53) | LMNATSHRMAPK1KDM4E | |
| SCHEMBL5949941 | 0.80 | LMNA (0.78) | LMNATSHRCYP1A2KDM4EPTGS1 | |
| SCHEMBL21393243 | 0.79 | LMNA (0.60) | LMNATSHRMAPK1KDM4EMAPT | |
| SCHEMBL21393244 | 0.79 | LMNA (0.60) | LMNATSHRMAPK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893588-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135826-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | claimed |