Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | OGA | O60502 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12878768 | 0.80 | HRH3 (0.60) | HRH3OGAGRM5GRM1SLC6A7 | |
| SCHEMBL11067902 | 0.77 | GRM5 (0.58) | HRH3GRM5GRM1SLC6A7NPC1 | |
| SCHEMBL4724942 | 0.77 | OGA (0.49) | HRH3OGAGRM5GRM1SLC6A7 | |
| SCHEMBL4724317 | 0.76 | NPC1 (0.48) | OGASLC6A7NPC1RAB9AMEN1 | |
| SCHEMBL29102030 | 0.76 | — | — | |
| SCHEMBL11075306 | 0.74 | GRM5 (0.55) | HRH3OGAGRM5GRM1SLC6A7 | |
| SCHEMBL5987878 | 0.74 | GRM5 (0.58) | HRH3GRM5GRM1SLC6A7NPC1 | |
| SCHEMBL11071509 | 0.74 | GRM5 (0.54) | HRH3OGAGRM5GRM1SLC6A7 | |
| SCHEMBL27722988 | 0.73 | GRM5 (0.61) | HRH3GRM5GRM1SLC6A7NPC1 | |
| SCHEMBL11075066 | 0.73 | GRM5 (0.51) | HRH3OGAGRM5GRM1SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |