Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | OGA | O60502 | 6/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29246743 | 0.85 | KDM4E (0.51) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3476407 | 0.84 | KDM4E (0.48) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4766661 | 0.82 | SMN1; SMN2 (0.61) | KDM4EALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL4723632 | 0.82 | SMN1; SMN2 (0.61) | KDM4EALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL7546262 | 0.78 | OGA (0.51) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10530529 | 0.78 | LMNA (0.53) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5962506 | 0.77 | OGA (0.54) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL16026595 | 0.76 | MEN1 (0.37) | RAB9AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL4724307 | 0.76 | HRH3 (0.52) | NPC1RAB9AALDH1A1OGAMEN1 | |
| SCHEMBL4723624 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |