Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18767460 | 0.81 | MAOB (0.53) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 | |
| SCHEMBL4723430 | 0.78 | CYP19A1 (0.57) | CYP19A1CYP11B1CYP11B2MAPTRAB9A | |
| SCHEMBL8298067 | 0.75 | MAOB (0.56) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 | |
| SCHEMBL12154961 | 0.74 | MRGPRX4 (0.48) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 | |
| SCHEMBL5659691 | 0.73 | MAOB (0.58) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 | |
| SCHEMBL27655217 | 0.72 | LTA4H (0.56) | CYP19A1CYP11B1CYP11B2AOC3MAOB | |
| SCHEMBL31364101 | 0.72 | KCNA3 (0.65) | CYP19A1CYP11B1CYP11B2MAPTRAB9A | |
| SCHEMBL5445170 | 0.72 | KCNA3 (0.65) | CYP19A1CYP11B1CYP11B2MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL11596441 | 0.72 | GAA (0.56) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 | |
| SCHEMBL11372714 | 0.72 | MAPT (0.56) | CYP19A1CYP11B1CYP11B2MAOBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934228-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | BRAF, RAF1, ARAF | CYP19A1 2386/4885CYP11B1 960/4885CYP11B2 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.