Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765086 | 0.77 | KDM4E (0.50) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL5622384 | 0.73 | HPGD (0.64) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL15512118 | 0.70 | KDM4E (0.68) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL7836288 | 0.69 | KDM4E (1.00) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL4724459 | 0.69 | KDM4E (0.70) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL4723975 | 0.69 | KDM4E (0.73) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL8216031 | 0.68 | AOC1 (0.52) | ALDH1A1KDM4EGLAGAACDK8 | |
| SCHEMBL19587052 | 0.68 | GAA (0.53) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL4766200 | 0.68 | KDM4E (0.44) | ALDH1A1KDM4EGLAGAAHPGD | |
| Hydrochloric Acid SCHEMBL28051932 | 0.67 | GAA (0.51) | ALDH1A1KDM4EGLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934228-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |