Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078048 | 0.80 | HTR2A (0.43) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL6370062 | 0.79 | MAPT (0.47) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL131957 | 0.77 | MAPT (0.45) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL131224 | 0.76 | MAPT (0.44) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL3565066 | 0.76 | MAPT (0.44) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL3560313 | 0.76 | MAPT (0.47) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL11333063 | 0.76 | LMNA (0.44) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL11806450 | 0.73 | LMNA (0.43) | HTR2AHTR2CLMNAMAPTHTT | |
| SCHEMBL3566138 | 0.72 | AR (0.46) | LMNAMAPTHTTALDH1A1TDP1 | |
| SCHEMBL28701077 | 0.72 | ALDH1A1 (0.48) | MAPTHTTALDH1A1CYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |