Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726605 | 0.80 | PRKCQ (0.36) | — | |
| SCHEMBL4580999 | 0.65 | CYP11B1 (0.46) | KDM1ACYP11B1CYP11B2PDE4APDE4C | |
| SCHEMBL18297999 | 0.63 | CYP11B2 (0.67) | CYP11B1CYP11B2 | |
| SCHEMBL4580915 | 0.62 | EGLN2 (0.48) | KDM1ACYP11B1CYP11B2EGLN2 | |
| SCHEMBL9151348 | 0.62 | CYP11B2 (0.66) | CYP11B1CYP11B2 | |
| SCHEMBL9612021 | 0.61 | CYP11B2 (0.68) | CYP11B1CYP11B2 | |
| SCHEMBL24137660 | 0.61 | KDM1A (0.64) | KDM1ACYP11B1CYP11B2 | |
| SCHEMBL14072361 | 0.61 | CYP11B1 (0.57) | CYP11B1CYP11B2EGLN2 | |
| SCHEMBL12012339 | 0.61 | CYP11B1 (0.66) | CYP11B1CYP11B2 | |
| SCHEMBL9445543 | 0.61 | CYP11B1 (0.42) | KDM1ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |