SCHEMBL9151348

SCHEMBL9151348

Cc1ccc(-c2ccc(C#N)c(F)c2)nc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 20/20 0.66
CYP11B1 P15538 19/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29195576 0.83 CYP11B2 (0.57) CYP11B2CYP11B1
SCHEMBL10716426 0.81 CYP11B1 (0.49) CYP11B2CYP11B1
SCHEMBL16215329 0.81 GRM5 (0.49) CYP11B2CYP11B1
SCHEMBL9151372 0.81 CYP11B2 (0.52) CYP11B2CYP11B1
SCHEMBL19243068 0.80 CCR1 (0.54) CYP11B2CYP11B1
SCHEMBL3480516 0.79 CYP11B2 (0.60) CYP11B2CYP11B1
SCHEMBL20459995 0.79 CYP11B2 (1.00) CYP11B2CYP11B1
SCHEMBL21243550 0.79 KCNJ1 (0.52) CYP11B2CYP11B1
SCHEMBL9151552 0.79 NPC1 (0.62) CYP11B2CYP11B1
SCHEMBL30751808 0.79 KCNJ1 (0.52) CYP11B2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0252961-B1 HETEROCYCLIC COMPOUNDS AS COMPONENTS OF LIQUID CRYSTAL PHASES MERCK PATENT GMBH (DE) 1995-02-08 EP claimed
EP-0252961-B1 HETEROCYCLIC COMPOUNDS AS COMPONENTS OF LIQUID CRYSTAL PHASES MERCK PATENT GMBH (DE) 1995-02-08 EP disclosed
US-4913837-A Heterocyclic compounds MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1990-04-03 US disclosed