Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005817 | 0.81 | OPRL1 (0.60) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3762803 | 0.78 | OPRL1 (0.57) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3762842 | 0.76 | OPRL1 (0.58) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3774344 | 0.76 | EGLN1 (0.44) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3766135 | 0.74 | OPRL1 (0.61) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3769763 | 0.73 | EGLN1 (0.48) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL3178584 | 0.73 | OPRL1 (0.66) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3773817 | 0.72 | EGLN1 (0.54) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3763129 | 0.72 | OPRM1 (0.55) | OPRL1KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL29444522 | 0.71 | DDR1 (0.59) | OPRL1DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909797-A2 | DIPIPERAZINYL KETONES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016496-A2 | DIPIPERAZINYL KETONES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |