Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725990 | 0.92 | MAPK1 (0.59) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL4728689 | 0.87 | PDE5A (0.55) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL4727580 | 0.85 | PDE5A (0.55) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL7473060 | 0.82 | STAT1 (0.64) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL4725805 | 0.81 | PDE11A (0.58) | PDE11A | |
| SCHEMBL4780205 | 0.81 | PDE11A (0.54) | PDE11A | |
| SCHEMBL7544551 | 0.79 | STAT1 (0.61) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL7465501 | 0.78 | STAT1 (0.56) | MAPK1PDE5AHTTSTAT1RAF1 | |
| SCHEMBL8217826 | 0.78 | PDE5A (0.50) | PDE5AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL4778469 | 0.77 | MAPK1 (0.65) | MAPK1PDE5AHTTSTAT1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020711-A1 | QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2008-02-21 | — | — | WO | disclosed |