Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | FGB | P02675 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274409 | 0.99 | MEN1 (0.55) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL6288073 | 0.84 | MEN1 (0.43) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL6274163 | 0.82 | MEN1 (0.62) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5083232 | 0.81 | KDM4E (0.57) | HSP90AA1HSP90AB1KDM4EMAPTALDH1A1 | |
| SCHEMBL4727333 | 0.80 | KDM4E (0.56) | HSP90AA1HSP90AB1KDM4EMAPTALDH1A1 | |
| SCHEMBL4727652 | 0.74 | MEN1 (0.43) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL4725352 | 0.74 | NSD2 (0.59) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5086649 | 0.73 | NSD2 (0.58) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| Quinocide SCHEMBL157174 | 0.72 | MEN1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 | |
| Quinocide SCHEMBL29720457 | 0.72 | MEN1 (1.00) | MEN1KMT2AHSP90AA1HSP90AB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |