Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | FGB | P02675 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288073 | 0.91 | MEN1 (0.43) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL5083233 | 0.81 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1KDM4EALDH1A1MAPT | |
| SCHEMBL4726086 | 0.81 | MEN1 (0.48) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL6268423 | 0.79 | MEN1 (0.47) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL6274409 | 0.76 | MEN1 (0.55) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL5083088 | 0.75 | TUBB4A (0.39) | KDM4EALDH1A1MAPTTSHRHTT | |
| SCHEMBL4725463 | 0.74 | MEN1 (0.56) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL5084097 | 0.72 | MAOA (0.43) | RAD52HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL6268701 | 0.72 | MEN1 (0.49) | MEN1KMT2ARAD52HSP90AA1HSP90AB1 | |
| SCHEMBL4726521 | 0.70 | MAOA (0.44) | RAD52HSP90AA1HSP90AB1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |