Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.47 |
| ▸ | HTT | P42858 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726544 | 0.92 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AROCK2ROCK1 | |
| SCHEMBL4780046 | 0.87 | TSHR (0.46) | SMN1; SMN2ROCK2ROCK1GAALMNA | |
| SCHEMBL4777271 | 0.87 | ROCK1 (0.48) | SMN1; SMN2ROCK2ROCK1LMNAMAPK1 | |
| SCHEMBL4725694 | 0.87 | ROCK1 (0.44) | ROCK2ROCK1MAPK1TRPV1 | |
| SCHEMBL4726154 | 0.86 | ROCK1 (0.42) | SMN1; SMN2ROCK2ROCK1LMNAMEN1 | |
| SCHEMBL4725491 | 0.86 | ROCK1 (0.47) | ROCK2ROCK1LMNAMAPK1TRPV1 | |
| SCHEMBL4726471 | 0.86 | ROCK1 (0.47) | ROCK2ROCK1LMNAMAPK1TRPV1 | |
| SCHEMBL4778546 | 0.86 | ROCK1 (0.44) | ROCK2ROCK1MAPK1TRPV1 | |
| Hydrochloric Acid SCHEMBL4779977 | 0.85 | ROCK1 (0.43) | ROCK2ROCK1MAPK1TRPV1 | |
| SCHEMBL4727100 | 0.84 | ROCK1 (0.42) | SMN1; SMN2ROCK2ROCK1MAPK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716320-B2 | Antibacteriall heterocyclic ureas | REPLIDYNE, INC. (US) | 2014-05-06 | — | — | US | claimed |
| US-20080207703-A1 | Antibacterial heterocyclic ureas | REPLIDYNE, INC. (US) | 2008-08-28 | — | — | US | claimed |
| WO-2008011191-A1 | ANTIBACTERIAL HETEROCYCLIC UREAS | REPLIDYNE, INC. (US) | 2008-01-24 | — | — | WO | claimed |
| US-8716320-B2 | Antibacteriall heterocyclic ureas | REPLIDYNE, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20080207703-A1 | Antibacterial heterocyclic ureas | REPLIDYNE, INC. (US) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207703-A1 | Antibacterial heterocyclic ureas | UMPS, UROD, UGP2 | SMN1; SMN2 4077/4885NPC1 2049/4885RAB9A 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.