Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.45 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725570 | 0.79 | IP6K1 (0.50) | IP6K1EGFRERBB2 | |
| SCHEMBL4729925 | 0.78 | KMO (0.44) | IP6K1EGFR | |
| SCHEMBL4725560 | 0.78 | MAPK1 (0.50) | MAPTIP6K1EGFRERBB2 | |
| SCHEMBL4729003 | 0.78 | CYSLTR1 (0.41) | EGFR | |
| SCHEMBL4728722 | 0.76 | ADORA2A (0.53) | MAPTMAOBIP6K1EGFRERBB2 | |
| SCHEMBL15175350 | 0.75 | MAPT (0.64) | POLBMAPTMAOBGPR34NR4A2 | |
| SCHEMBL5025938 | 0.75 | MRGPRX4 (0.69) | POLBMAPTMAOBNR4A2MRGPRX4 | |
| SCHEMBL855876 | 0.72 | IP6K1 (0.56) | MAOBIP6K1EGFRERBB2MAOA | |
| SCHEMBL1875717 | 0.70 | NR1H2 (0.49) | POLBMAPTMAOBNR4A2MRGPRX4 | |
| SCHEMBL15712923 | 0.70 | ADORA2A (0.49) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |