Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727365 | 0.87 | PIK3CD (0.51) | CYSLTR1GPBAR1CYSLTR2PDE10APIK3CD | |
| SCHEMBL4727531 | 0.84 | EGFR (0.46) | PDE10APIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL4730048 | 0.82 | PDE10A (0.44) | CYSLTR1GPBAR1CYSLTR2PDE10APIK3CD | |
| SCHEMBL4727502 | 0.82 | PDE10A (0.43) | CYSLTR1GPBAR1CYSLTR2PDE10APIK3CD | |
| SCHEMBL4725187 | 0.79 | GPBAR1 (0.47) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL4725552 | 0.78 | POLB (0.47) | EGFR | |
| SCHEMBL4725039 | 0.76 | CYSLTR1 (0.57) | CYSLTR1GPBAR1CYSLTR2PDE10APIK3CD | |
| SCHEMBL4725058 | 0.74 | CYSLTR1 (0.55) | CYSLTR1GPBAR1CYSLTR2PDE10APIK3CD | |
| SCHEMBL4780024 | 0.72 | CYSLTR1 (0.51) | CYSLTR1GPBAR1CYSLTR2PDE10AMTOR | |
| SCHEMBL4725523 | 0.72 | PDE10A (0.56) | CYSLTR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |