Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | NEK2 | P51955 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3761910 | 0.93 | NOS1 (0.56) | NOS1PIK3CAPIK3CDPIK3CGATR | |
| SCHEMBL4725703 | 0.80 | NOS1 (0.49) | NOS1PIK3CAPIK3CDPIK3CGATR | |
| SCHEMBL3770114 | 0.76 | NOS1 (0.64) | NOS1ATRJAK2ADK | |
| SCHEMBL3766613 | 0.76 | NOS1 (0.63) | NOS1PIK3CAPIK3CDPIK3CGATR | |
| SCHEMBL4450316 | 0.75 | NOS1 (0.82) | NOS1PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL3752841 | 0.75 | PIK3CA (0.49) | NOS1PIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL4458075 | 0.73 | NOS1 (0.64) | NOS1PIK3CAPIK3CGATRMTOR | |
| SCHEMBL4448737 | 0.72 | NOS1 (0.61) | NOS1ATRJAK2STAT3 | |
| SCHEMBL3770209 | 0.71 | NOS1 (0.71) | NOS1PIK3CAPIK3CGATRMTOR | |
| SCHEMBL3769685 | 0.71 | NOS1 (0.73) | NOS1PIK3CAPIK3CGATRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009079-A2 | SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |