Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.74 |
| ▸ | HTR1A | P08908 | 7/20 | 0.65 |
| ▸ | HTR2A | P28223 | 7/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | HTR2B | P41595 | 3/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | DRD1 | P21728 | 2/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.65 |
| ▸ | DRD5 | P21918 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HTR7 | P34969 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 2/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | MLNR | O43193 | 1/20 | 0.65 |
| ▸ | HTR3B | O95264 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728160 | 0.97 | DRD2 (0.74) | DRD2HTR1AHTR2ADRD3HTR2B | |
| SCHEMBL4729770 | 0.93 | DRD2 (0.83) | DRD2HTR1AHTR2ADRD3HTR2B | |
| SCHEMBL4729234 | 0.90 | DRD2 (0.83) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL4725817 | 0.88 | DRD2 (0.59) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL253847 | 0.85 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2B | |
| SCHEMBL253342 | 0.84 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2B | |
| SCHEMBL4726614 | 0.83 | HTR1A (0.70) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL4725837 | 0.83 | DRD2 (0.87) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL253322 | 0.82 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2B | |
| SCHEMBL253079 | 0.81 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |