Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775856 | 0.82 | PRKCI (0.39) | PIK3CAPIK3R1KDM4EMTORPRKCI | |
| SCHEMBL9678323 | 0.80 | PIK3CA (0.85) | PIK3CAPIK3R1KDM4EMTORPIK3CD | |
| SCHEMBL4779719 | 0.77 | NMT1 (0.37) | PIK3CAPIK3R1KDM4EMTORPRKCI | |
| SCHEMBL18894266 | 0.74 | PIK3CA (0.82) | PIK3CAPIK3R1KDM4EMTORPIK3CD | |
| SCHEMBL18894265 | 0.69 | PIK3CA (0.70) | PIK3CAPIK3R1KDM4EMTORPIK3CD | |
| SCHEMBL15542887 | 0.69 | PRKCQ (0.43) | KDM4EPIK3CBALDH1A1HPGD | |
| SCHEMBL12110480 | 0.69 | PIK3CA (0.72) | PIK3CAPIK3R1KDM4EMTORPIK3CD | |
| SCHEMBL4781933 | 0.67 | HTR2C (0.42) | PIK3CAKDM4EPIK3CB | |
| SCHEMBL13298350 | 0.66 | PIK3CA (0.72) | PIK3CAPIK3R1KDM4EMTORPIK3CD | |
| SCHEMBL189594 | 0.66 | PIK3CA (0.72) | PIK3CAPIK3R1KDM4EMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | PIK3CA 1066/4885PIK3R1 1384/4885KDM4E 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.