Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776431 | 0.84 | MAPK1 (0.40) | HTR2CMAPK1HSD17B10L3MBTL1PRKCQ | |
| SCHEMBL4775856 | 0.82 | PRKCI (0.39) | HTR2CPRKCQPRKCDKDM4EHTR6 | |
| SCHEMBL16696294 | 0.72 | L3MBTL1 (0.66) | HTR2CMAPK1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL190563 | 0.70 | PIK3CA (0.58) | HTR2CMAPK1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL4781601 | 0.69 | PRKCQ (0.41) | PRKCQPRKCDHTR6SPASTROCK2 | |
| SCHEMBL3155004 | 0.69 | PRKCQ (0.43) | HSD17B10PRKCQPRKCDROCK2ROCK1 | |
| SCHEMBL4778367 | 0.69 | PRKCQ (0.51) | PRKCQPRKCDHTR6ROCK2ROCK1 | |
| SCHEMBL4439640 | 0.68 | ADORA2A (0.44) | HTR2CMAPK1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL4725834 | 0.67 | PIK3CA (0.64) | KDM4EPIK3CAPIK3CB | |
| SCHEMBL4779719 | 0.66 | NMT1 (0.37) | HTR2CPRKCQPRKCDKDM4EUSP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | HTR2C 232/4885MAPK1 862/4885HSD17B10 4228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.