SCHEMBL4725847

SCHEMBL4725847

O=C(OCc1ccc([N+](=O)[O-])cc1)OC(=O)OCc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.59
IDO1 P14902 2/20 0.58
RAB9A P51151 2/20 0.56
AKR1C3 P42330 1/20 0.56
HTT P42858 2/20 0.52
MAOB P27338 1/20 0.51
ALDH1A1 P00352 2/20 0.51
TSHR P16473 1/20 0.50
MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL37664 0.93 HTR2A (0.62) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL8691250 0.90 HTR2A (0.54) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL10801165 0.90 HTR2A (0.58) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL1029307 0.89 HTR2A (0.59) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL9676749 0.86 HTR2A (0.57) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL11161827 0.86 HTR2A (0.57) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL6141208 0.86 HTR2A (0.64) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL6645015 0.86 RAB9A (0.61) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL7289565 0.86 IDO1 (0.64) HTR2AIDO1RAB9AAKR1C3HTT
SCHEMBL7289559 0.86 HTR2A (0.57) HTR2AIDO1RAB9AAKR1C3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008026222-A2 PROCESS AND INTERMEDIATES OF 2,2' DIFLUORONUCLEOSIDES SHILPA MEDICARE LTD (IN) 2008-03-06 WO disclosed
EP-0362902-B1 Process and intermediates for beta-lactam antibiotics HARVARD COLLEGE (US) 1996-01-17 EP disclosed
US-5091525-A 7beta- 2'-(R)-2'-(p-hydroxyphenyl-2'-amino-acetamido!-3-chloro -3-(1-carbadethiacephem)-4-carboxylic acid ELI LILLY AND COMPANY (US) 1992-02-25 US disclosed
EP-0209352-B1 PROCESS AND INTERMEDIATES FOR BETA-LACTAM ANTIBIOTICS THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1991-05-02 EP disclosed
EP-0211540-B1 INTERMEDIATES AND PROCESS FOR ANTIBIOTICS THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1990-05-16 EP disclosed
EP-0362902-A2 Process and intermediates for beta-lactam antibiotics THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1990-04-11 EP disclosed
US-4870169-A Intermediates for beta-lactam antibiotics PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1989-09-26 US disclosed
US-4820816-A 3-trifuoromethylsulfonyloxy-substituted 1-carbacephalosporins as intermediates for antibiotics PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1989-04-11 US disclosed
US-4778884-A REACTING TRIFLUOROMETHYLSULFONYLOXY COMPOUND WITH LITHIUM HALIDE IN APROTIC POLAR SOLVENT PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) 1988-10-18 US disclosed
US-4775752-A Process and intermediates for beta-lactam antibiotics THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1988-10-04 US disclosed
US-4734495-A Process and intermediates for beta-lactam antibiotics PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1988-03-29 US disclosed
US-4673737-A ANTIBIOTICS/ HARVARD UNIVERSITY (US) 1987-06-16 US disclosed
US-4665171-A CARBACEPHALOSPORINS HARVARD UNIVERSITY (US) 1987-05-12 US disclosed
EP-0211540-A1 Intermediates and process for antibiotics THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1987-02-25 EP disclosed
EP-0209352-A2 Process and intermediates for beta-lactam antibiotics THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1987-01-21 EP disclosed