Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144637 | 0.85 | LMNA (0.52) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL17144281 | 0.83 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL9405372 | 0.80 | POLB (0.73) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL30690056 | 0.80 | LMNA (0.47) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL30376769 | 0.78 | LMNA (0.51) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL27842859 | 0.78 | POLB (0.58) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL24137712 | 0.77 | POLB (0.60) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL30659245 | 0.77 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL30136060 | 0.77 | POLB (0.56) | POLBSMN1; SMN2LMNAOPRD1OPRK1 | |
| SCHEMBL346648 | 0.77 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2LMNAOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |