Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725924 | 0.94 | MAPK14 (0.43) | RAF1BRAFRETMAPK14 | |
| SCHEMBL4783017 | 0.93 | MAPK14 (0.41) | RAF1BRAFRETMAPK14 | |
| SCHEMBL4727320 | 0.92 | CNR2 (0.42) | RAF1BRAFRETMAPK14 | |
| SCHEMBL4730967 | 0.91 | RAF1 (0.44) | EGLN1RAF1BRAFGSK3AMAPK14 | |
| SCHEMBL4725979 | 0.90 | MAPK14 (0.43) | EGLN1RAF1BRAFMAPK14 | |
| SCHEMBL4729211 | 0.89 | MAPK14 (0.40) | EGLN1RAF1BRAFRETMAPK14 | |
| SCHEMBL4725975 | 0.88 | MAPK14 (0.41) | EGLN1RAF1BRAFMAPK14 | |
| SCHEMBL4727823 | 0.85 | MAPK14 (0.45) | RAF1BRAFMAPK14 | |
| SCHEMBL4728370 | 0.85 | MAPK14 (0.45) | RAF1BRAFMAPK14 | |
| SCHEMBL4727004 | 0.85 | RAF1 (0.43) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |