Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127669 | 0.90 | AVPR1A (0.34) | AVPR1AABCB11 | |
| SCHEMBL26103675 | 0.85 | RAD52 (0.35) | ALDH1A1GAALMNAKDM4EPKM | |
| SCHEMBL1619061 | 0.84 | ALDH1A1 (0.35) | ALDH1A1GAALMNAKDM4EPKM | |
| SCHEMBL3126033 | 0.79 | MEN1 (0.34) | AVPR1AABCB11 | |
| Hydrochloric Acid SCHEMBL4265154 | 0.77 | MEN1 (0.33) | AVPR1AABCB11 | |
| SCHEMBL4670377 | 0.76 | ALDH1A1 (0.48) | ALDH1A1PKMSMN1; SMN2MAPK1 | |
| SCHEMBL4669376 | 0.73 | HRH3 (0.33) | ALDH1A1LMNAKDM4E | |
| SCHEMBL3311902 | 0.72 | KDM4E (0.33) | ALDH1A1KDM4E | |
| SCHEMBL2334083 | 0.72 | EBP (0.56) | ALDH1A1GAAKDM4EDRD2HTR2A | |
| SCHEMBL2334088 | 0.72 | EBP (0.56) | ALDH1A1GAAKDM4EDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |