Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667545 | 0.75 | LMNA (0.49) | HRH3ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL4726752 | 0.73 | ALDH1A1 (0.35) | ALDH1A1KDM4ELMNA | |
| SCHEMBL8814790 | 0.71 | CXCR4 (0.43) | HRH3ALDH1A1KDM4ELMNAHRH2 | |
| SCHEMBL3311902 | 0.70 | KDM4E (0.33) | ALDH1A1KDM4E | |
| SCHEMBL3127669 | 0.69 | AVPR1A (0.34) | POLB | |
| SCHEMBL8939921 | 0.68 | GAA (0.53) | HRH3ALDH1A1KDM4ELMNA | |
| SCHEMBL3126033 | 0.68 | MEN1 (0.34) | — | |
| SCHEMBL31243628 | 0.67 | CYP2D6 (0.54) | HRH3ALDH1A1KDM4EPOLB | |
| SCHEMBL22266346 | 0.67 | CXCR4 (0.44) | ALDH1A1KDM4ELMNAHRH2HRH1 | |
| SCHEMBL29056699 | 0.67 | HRH3 (0.41) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |