Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.46 |
| ▸ | RXRB | P28702 | 8/20 | 0.46 |
| ▸ | RXRG | P48443 | 4/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235447 | 0.84 | RXRA (0.47) | RXRARXRBRXRGFOLH1NR1H4 | |
| SCHEMBL545316 | 0.84 | RXRA (0.47) | RXRARXRBRXRGFOLH1NR1H4 | |
| SCHEMBL5335840 | 0.81 | NOTUM (0.46) | TDP1 | |
| SCHEMBL166878 | 0.80 | RXRB (0.59) | RXRARXRBRXRGNR1H4TDP1 | |
| SCHEMBL501957 | 0.80 | RXRB (0.64) | RXRARXRBRXRGNR1H4TDP1 | |
| SCHEMBL2226759 | 0.80 | TTR (0.44) | RXRARXRBFOLH1TDP1TP53 | |
| SCHEMBL1866724 | 0.80 | TTR (0.44) | FOLH1TDP1TP53MAPTALOX15 | |
| Acetic Acid SCHEMBL28155950 | 0.79 | TPMT (0.43) | RXRARXRBFOLH1TDP1TP53 | |
| Hydrochloric Acid SCHEMBL4585979 | 0.78 | RXRB (0.57) | RXRARXRBRXRGNR1H4TDP1 | |
| Hydrochloric Acid SCHEMBL11879619 | 0.78 | RXRB (0.57) | RXRARXRBRXRGNR1H4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |