Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039680 | 0.85 | AURKA (0.62) | AURKAROCK1 | |
| SCHEMBL2464073 | 0.81 | SCN9A (0.55) | AURKAROCK1 | |
| SCHEMBL4903688 | 0.81 | MAPK8 (0.63) | AURKA | |
| SCHEMBL3747896 | 0.81 | CAMKK2 (0.80) | AURKA | |
| SCHEMBL6583846 | 0.80 | SCN9A (0.54) | AURKAROCK1 | |
| SCHEMBL4903516 | 0.80 | MAPK8 (0.68) | AURKA | |
| SCHEMBL4712432 | 0.80 | ABL1 (0.61) | AURKA | |
| SCHEMBL11309017 | 0.79 | RHOA (0.54) | AURKAROCK1 | |
| SCHEMBL4895454 | 0.79 | ABL1 (0.80) | — | |
| SCHEMBL4237476 | 0.78 | AURKA (1.00) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |