Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727810 | 0.81 | POLB (0.51) | NPC1RAB9APOLBCASP3ALDH1A1 | |
| SCHEMBL7229196 | 0.79 | NPC1 (0.61) | NPC1RAB9APOLBCASP3SMN1; SMN2 | |
| SCHEMBL3230293 | 0.78 | NPC1 (0.59) | NPC1RAB9APOLBCASP3SMN1; SMN2 | |
| SCHEMBL3105408 | 0.76 | RAB9A (0.60) | NPC1RAB9APOLBCASP3SMN1; SMN2 | |
| SCHEMBL8789037 | 0.76 | HDAC1 (0.62) | NPC1RAB9APOLBCASP3SMN1; SMN2 | |
| SCHEMBL14183610 | 0.75 | SMN1; SMN2 (0.66) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL18640773 | 0.74 | POLB (0.65) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3237870 | 0.74 | NPC1 (0.54) | NPC1RAB9APOLBCASP3ALDH1A1 | |
| SCHEMBL14291607 | 0.74 | NPC1 (0.51) | NPC1RAB9APOLBCASP3ALDH1A1 | |
| SCHEMBL3782118 | 0.73 | NPC1 (0.68) | NPC1RAB9APOLBCASP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008022467-A1 | 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008022467-A1 | 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2008-02-28 | — | — | WO | disclosed |