Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728048 | 0.90 | AURKA (0.52) | AURKACDK2CHEK1PDPK1CHEK2 | |
| SCHEMBL4725774 | 0.88 | EPHB4 (0.43) | AURKACDK2CDK1PIM1AURKB | |
| SCHEMBL4779934 | 0.83 | AURKA (0.52) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4725764 | 0.81 | AURKA (0.51) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4728068 | 0.80 | CTSA (0.38) | — | |
| SCHEMBL4727393 | 0.79 | AURKA (0.52) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4727991 | 0.77 | CDK2 (0.45) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4730819 | 0.77 | CDK2 (0.49) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4728077 | 0.77 | EGFR (0.59) | AURKACDK2CHEK1IKBKBNPC1 | |
| SCHEMBL4779894 | 0.75 | IGF1R (0.49) | AURKACDK2NPC1CDK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |