Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730819 | 0.84 | CDK2 (0.49) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4779934 | 0.84 | AURKA (0.52) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4726184 | 0.81 | CDK2 (0.44) | CDK2CDK4PLK1AURKAMAPK1 | |
| SCHEMBL4727989 | 0.80 | CDK2 (0.47) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4729983 | 0.78 | PGR (0.45) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4727398 | 0.77 | AURKA (0.52) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4725764 | 0.76 | AURKA (0.51) | CDK2CDK4PLK1AURKANPC1 | |
| SCHEMBL4779918 | 0.76 | AURKA (0.52) | AURKASYK | |
| SCHEMBL4729366 | 0.75 | SLC10A1 (0.36) | CDK2PLK1MAPTMAPK1PIM1 | |
| SCHEMBL4727466 | 0.73 | AURKA (0.52) | CDK2PLK1AURKANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |