SCHEMBL4727467

SCHEMBL4727467

CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCc2cc(O)c(C(C)(C)C)cc2O1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.52
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
TP53 P04637 1/20 0.52
CYP1A2 P05177 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
KMT2A Q03164 1/20 0.52
HSD17B10 Q99714 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
PPARG P37231 10/20 0.46
ESRRA P11474 1/20 0.46
FFAR1 O14842 7/20 0.42
PPARA Q07869 2/20 0.42
HRH3 Q9Y5N1 1/20 0.41
MPC2 O95563 2/20 0.41
CYP2C8 P10632 2/20 0.41
CYP2C9 P11712 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10639115 0.93 MEN1 (0.44) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10636511 0.93 CYP3A4 (0.47) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL9632185 0.92 CYP3A4 (0.49) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL19454900 0.89 KMT2A (0.39) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10638937 0.89 ALDH1A1 (0.55) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10641679 0.88 CYP3A4 (0.49) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10639855 0.88 MEN1 (0.48) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10639191 0.87 MEN1 (0.52) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10642072 0.86 CYP3A4 (0.52) CYP3A4MEN1ALDH1A1TP53CYP1A2
SCHEMBL10638777 0.86 MEN1 (0.35) CYP3A4MEN1ALDH1A1TP53CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0919232-B1 Composition for use in the treatment and prevention of hyperuricemia SANKYO CO (JP) 2004-10-06 EP claimed
EP-0796618-B1 Treatment and prophylaxis of pancreatitis SANKYO CO (JP) 2002-01-30 EP claimed
WO-2000041690-A9 USE OF THIAZOLIDINEDIONES TO AMELIORATE THE ADVERSE CONSEQUENCES OF MYOCARDIAL ISCHEMIA ON MYOCARDIAL FUNCTION AND METABOLISM UNIV CALIFORNIA (US) 2001-10-11 WO claimed
WO-2000041690-A1 USE OF THIAZOLIDINEDIONES TO AMELIORATE THE ADVERSE CONSEQUENCES OF MYOCARDIAL ISCHEMIA ON MYOCARDIAL FUNCTION AND METABOLISM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-07-20 WO claimed
EP-0919232-A1 Composition for use in the treatment and prevention of hyperuricemia Sankyo Company Limited (JP) 1999-06-02 EP claimed
EP-0796618-A1 Treatment and prophylaxis of pancreatitis SANKYO COMPANY LIMITED (JP) 1997-09-24 EP claimed
EP-0783888-A1 Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis SANKYO COMPANY LIMITED (JP) 1997-07-16 EP claimed
EP-0439321-B1 Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use SANKYO CO (JP) 1995-03-15 EP claimed
EP-0439321-A2 Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use Sankyo Company Limited (JP) 1991-07-31 EP claimed
US-20210163468-A1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY THE SCHEPENS EYE RESEARCH INSTITUTE, INC. 2021-06-03 US disclosed
US-20190152967-A1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY THE SCHEPENS EYE RESEARCH INSTITUTE, INC. 2019-05-23 US disclosed
WO-2017176770-A1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY THE SCHEPENS EYE RESEARCH INSTITUTE, INC. (US) 2017-10-12 WO disclosed
WO-2008021210-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS COMBINATORX, INCORPORATED (US) 2008-02-21 WO disclosed
US-20080044390-A1 Methods and compositions for the treatment of neurodegenerative disorders CHDI, INCORPORATED 2008-02-21 US disclosed
EP-0439321-A2 Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use Sankyo Company Limited (JP) 1991-07-31 EP disclosed
EP-0207581-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE SANKYO COMPANY LIMITED (JP) 1990-09-12 EP disclosed
EP-0139421-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM SANKYO COMPANY LIMITED (JP) 1988-04-27 EP disclosed
EP-0207581-A2 Thiazolidine derivatives, their preparation and use SANKYO COMPANY LIMITED (JP) 1987-01-07 EP disclosed
US-4572912-A Thiazolidine derivatives, their preparation and compositions containing them SANKYO COMPANY LIMITED (JP) 1986-02-25 US disclosed
EP-0139421-A1 Thiazolidine derivatives, their preparation and compositions containing them SANKYO COMPANY LIMITED (JP) 1985-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152967-A1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY PPARG, PPARA, PPARD CYP3A4 4016/4885MEN1 4856/4885ALDH1A1 572/4885
US-20210163468-A1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA SELECTIVE AGONISTS FOR INHIBITION OF RETINAL PIGMENT EPITHELIUM DEGENERATION OR GEOGRAPHIC ATROPHY PPARG, PPARA, PPARD CYP3A4 4059/4885MEN1 4858/4885ALDH1A1 612/4885
US-20080044390-A1 Methods and compositions for the treatment of neurodegenerative disorders HTT, SNCA, NLN CYP3A4 4801/4885MEN1 3687/4885ALDH1A1 2348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.