Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680515 | 0.84 | METAP1 (0.46) | METAP1ATRNPC1CA1CA2 | |
| SCHEMBL14291444 | 0.79 | ALDH1A1 (0.42) | METAP1ATRNPC1CA1CA12 | |
| SCHEMBL9291119 | 0.77 | METAP1 (0.50) | METAP1ATRNPC1CA1CA2 | |
| SCHEMBL14510093 | 0.76 | METAP1 (0.49) | METAP1NPC1CA1CA12CA9 | |
| SCHEMBL437283 | 0.75 | METAP1 (0.48) | METAP1ATRNPC1CA1CA12 | |
| SCHEMBL395773 | 0.75 | METAP1 (0.48) | METAP1ATRNPC1CA1CA12 | |
| SCHEMBL11564693 | 0.75 | METAP1 (0.48) | METAP1ATRNPC1CA1CA2 | |
| SCHEMBL29960306 | 0.75 | MAPT (0.42) | METAP1CA1CA2CA12CA9 | |
| SCHEMBL29960699 | 0.75 | MAPT (0.42) | METAP1CA1CA2CA12CA9 | |
| SCHEMBL7461547 | 0.74 | METAP1 (0.47) | METAP1ATRNPC1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008022467-A1 | 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008022467-A1 | 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2008-02-28 | — | — | WO | disclosed |