Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | WHR1 | P49842 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726716 | 0.94 | RAB9A (0.46) | EGFRRAB9AABCB1CYP3A4PDE10A | |
| SCHEMBL4727754 | 0.91 | EGFR (0.45) | EGFRRAB9AABCB1CYP3A4PDE10A | |
| SCHEMBL4728986 | 0.91 | EGFR (0.45) | EGFRRAB9AABCB1CYP3A4PDE10A | |
| SCHEMBL4728717 | 0.80 | RAB9A (0.52) | RAB9APDE10AMAPTTP53HTT | |
| SCHEMBL4782102 | 0.77 | WHR1 (0.61) | EGFRHTTWHR1ATMHPGD | |
| SCHEMBL4727752 | 0.77 | PDE3A (0.71) | PDE10A | |
| SCHEMBL4728469 | 0.76 | PDE10A (0.47) | EGFRPDE10AHTTWHR1HPGD | |
| SCHEMBL4728977 | 0.76 | PDE10A (0.47) | EGFRPDE10AHTTWHR1HPGD | |
| SCHEMBL4728758 | 0.75 | RAB9A (0.53) | RAB9APDE10AMAPTTP53HTT | |
| SCHEMBL4725258 | 0.74 | KDM1A (0.57) | EGFRHTTWHR1ATMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |