Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 5/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735899 | 0.69 | GAA (0.43) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL5080644 | 0.68 | KDM4E (0.39) | GAAPOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL441572 | 0.67 | NFKBIA (0.52) | GAAPOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12120522 | 0.66 | NCF1 (0.45) | GAAPOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6636747 | 0.66 | CCR1 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C9CYP11B1 | |
| SCHEMBL11690033 | 0.66 | MEN1 (0.44) | GAAGFERCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2735020 | 0.66 | ALDH1A1 (0.46) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL3580491 | 0.65 | ALDH1A1 (0.53) | GAAPOLBGFERP2RX3P2RX2 | |
| SCHEMBL2269444 | 0.65 | NPC1 (0.50) | DHFRCYP1A2CYP11B1CYP11B2MEN1 | |
| SCHEMBL9406604 | 0.65 | NPC1 (0.46) | POLBALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |