Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794353 | 0.96 | PDE10A (0.46) | PDE10ACYP1A2HCRTR1HCRTR2BCHE | |
| SCHEMBL4727776 | 0.96 | PDE10A (0.46) | PDE10ACYP1A2HCRTR1HCRTR2BCHE | |
| SCHEMBL4729965 | 0.86 | HDAC6 (0.47) | PDE10ACYP1A2HCRTR1HCRTR2HDAC6 | |
| SCHEMBL4729821 | 0.85 | PDE10A (0.48) | PDE10ACYP1A2HCRTR1HCRTR2HDAC6 | |
| SCHEMBL4729506 | 0.84 | HDAC6 (0.49) | PDE10ACYP1A2HDAC6ADRA1AADRA1B | |
| SCHEMBL4726934 | 0.83 | HDAC6 (0.45) | PDE10ACYP1A2HDAC6 | |
| SCHEMBL4728780 | 0.83 | PDE10A (0.46) | PDE10ACYP1A2HCRTR1HCRTR2BCHE | |
| SCHEMBL4725564 | 0.83 | HDAC6 (0.44) | PDE10ACYP1A2HCRTR1HCRTR2HDAC6 | |
| SCHEMBL4781644 | 0.78 | IRAK1 (0.52) | HDAC6 | |
| SCHEMBL4725230 | 0.74 | ACHE (0.55) | PDE10AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |