Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583451 | 0.93 | PKM (0.49) | PKMALOX15CASP1HSD17B10ALDH1A1 | |
| SCHEMBL4582465 | 0.93 | PKM (0.50) | KDM4EMAPTMAPK1PKMALOX15 | |
| SCHEMBL4728704 | 0.88 | EGFR (0.46) | MAPTMAPK1ALDH1A1 | |
| SCHEMBL4583908 | 0.86 | MEN1 (0.47) | — | |
| SCHEMBL4582318 | 0.86 | MEN1 (0.56) | PKMALOX15CASP1HSD17B10ALDH1A1 | |
| SCHEMBL4582248 | 0.85 | PDGFRB (0.45) | KDM4EMAPTMAPK1ALDH1A1 | |
| SCHEMBL4581520 | 0.85 | PDGFRB (0.55) | PKMALOX15CASP1HSD17B10 | |
| SCHEMBL4583138 | 0.84 | ALDH1A1 (0.58) | KDM4EMAPTMAPK1PKMALOX15 | |
| SCHEMBL4582154 | 0.82 | ALDH1A1 (0.52) | KDM4EMAPTMAPK1PKMALOX15 | |
| SCHEMBL4583022 | 0.82 | PKM (0.52) | KDM4EMAPTMAPK1PKMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008028690-A1 | 1-(HET)ARYL-3-[HETARYL-PIPERIDIN-4-YL]-THIOUREAS AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |