Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766935 | 0.92 | NOTUM (0.49) | MCHR1NOTUMHDAC6HDAC8 | |
| SCHEMBL4858086 | 0.86 | MCHR1 (0.61) | MCHR1NOTUMHRH3 | |
| SCHEMBL5432297 | 0.84 | MCHR1 (0.62) | MCHR1HRH3CTNNB1WNT3A | |
| SCHEMBL4850684 | 0.80 | MCHR1 (0.61) | MCHR1HRH3CTNNB1WNT3A | |
| SCHEMBL11677470 | 0.77 | RAB9A (0.53) | MCHR1KDM4EL3MBTL1CTNNB1WNT3A | |
| SCHEMBL7285536 | 0.77 | NOTUM (0.60) | NOTUMHDAC6HDAC8 | |
| SCHEMBL4730749 | 0.76 | NOTUM (0.47) | NOTUMHRH3 | |
| SCHEMBL7277193 | 0.76 | NOTUM (0.58) | NOTUMHDAC6HDAC8KDM4E | |
| SCHEMBL14590639 | 0.74 | HSD17B3 (0.57) | NOTUMHDAC6HDAC8KDM4E | |
| SCHEMBL16284194 | 0.74 | NOTUM (0.60) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |