Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 16/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.67 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218604 | 0.95 | SIRT1 (0.67) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL8225273 | 0.95 | SIRT1 (0.67) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL8211125 | 0.95 | SIRT1 (0.67) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL4728208 | 0.90 | SIRT1 (0.73) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL4726705 | 0.89 | SIRT1 (0.59) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL4726038 | 0.84 | SIRT1 (0.59) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL4725227 | 0.82 | MEN1 (0.70) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL1874310 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL1870769 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL1275557 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008019825-A1 | USE OF TRICYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF MUSCULAR DISEASES | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008019825-A1 | USE OF TRICYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF MUSCULAR DISEASES | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-02-21 | — | — | WO | disclosed |