Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794320 | 0.87 | PIK3CA (0.48) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4727993 | 0.86 | PIK3CA (0.42) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4727905 | 0.84 | ATR (0.49) | LMNAHSD17B10HTTPIK3CAMTOR | |
| SCHEMBL4729174 | 0.81 | KDM4E (0.41) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4729907 | 0.80 | JAK2 (0.51) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4795569 | 0.80 | PIK3CA (0.45) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4728335 | 0.80 | JAK2 (0.48) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4730280 | 0.77 | JAK2 (0.43) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL4730204 | 0.74 | MOK (0.41) | HSD17B10PIK3CAMTORPIK3CGKDM4E | |
| SCHEMBL4727870 | 0.72 | PIK3CB (0.48) | LMNAHSD17B10PIK3CAMTORNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |