Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794320 | 0.89 | PIK3CA (0.48) | KDM4EL3MBTL1TDP1LMNAATM | |
| SCHEMBL4795569 | 0.83 | PIK3CA (0.45) | LMNAPIK3CAPIK3R1HSD17B10POLB | |
| SCHEMBL4730536 | 0.83 | ATR (0.43) | KDM4ELMNANPSR1PIK3CAHSD17B10 | |
| SCHEMBL4728451 | 0.81 | LMNA (0.48) | KDM4EL3MBTL1TDP1LMNAATM | |
| SCHEMBL4727993 | 0.79 | PIK3CA (0.42) | KDM4EL3MBTL1TDP1LMNAPIK3CA | |
| SCHEMBL4726457 | 0.74 | PIK3CB (0.48) | KDM4ELMNANPSR1PIK3CAHSD17B10 | |
| SCHEMBL4727870 | 0.74 | PIK3CB (0.48) | KDM4ELMNANPSR1PIK3CAHSD17B10 | |
| SCHEMBL4729907 | 0.74 | JAK2 (0.51) | LMNAPIK3CAHSD17B10POLBHTT | |
| SCHEMBL4728335 | 0.73 | JAK2 (0.48) | LMNAPIK3CAHSD17B10POLBHTT | |
| SCHEMBL4731075 | 0.73 | HTT (0.49) | KDM4ELMNANPSR1PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |