Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727055 | 0.86 | PIK3CA (0.41) | PIK3CAPIK3CGMTORHTTHSD17B10 | |
| SCHEMBL4728451 | 0.86 | LMNA (0.48) | PIK3CAPIK3CGMTORLMNAPOLB | |
| SCHEMBL4794320 | 0.82 | PIK3CA (0.48) | PIK3CAPIK3CGMTORLMNAPOLB | |
| SCHEMBL4795569 | 0.82 | PIK3CA (0.45) | PIK3CAPIK3CGMTORLMNAPOLB | |
| SCHEMBL4729174 | 0.79 | KDM4E (0.41) | PIK3CAMTORLMNAPOLBHTT | |
| SCHEMBL3985383 | 0.77 | HPGDS (0.52) | HPGDSHPGDCD274 | |
| SCHEMBL4838764 | 0.76 | PIK3CB (0.58) | PIK3CAPIK3CGMTORPIK3CDPIK3CB | |
| SCHEMBL4729907 | 0.76 | JAK2 (0.51) | PIK3CAPIK3CGMTORLMNAPOLB | |
| SCHEMBL4728335 | 0.75 | JAK2 (0.48) | PIK3CAPIK3CGMTORLMNAPOLB | |
| SCHEMBL4730280 | 0.75 | JAK2 (0.43) | PIK3CAPIK3CGMTORHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |